부산대학교 도서관

Background. Regular monitoring of liver complications is crucial to reduce morbidity and mortality in patients with delta viral liver cirrhosis. Aim and Objectives. To determine the frequency and factors associated with clinical, laboratory and imaging monitoring to identify events of liver decompensation and hepatocellular carcinoma in patients with delta viral liver cirrhosis. Methods. Retrospective cohort study of patients with delta viral cirrhosis (n=144) monitored for 4 years between 2018 and 2022, within the Gastroenterology Clinic, Republican Clinical Hospital, Chisinau. We calculated the proportion of patients monitored for liver decompensation and identified the factors associated with suboptimal monitoring. Results. mean age 52 years, 58% men; 73% come from the south and center of Moldova. Only 20.8% (n=30) of patients had surveillance for HCC and 27.08% (n=39) for liver decompensation throughout the study period. During follow-up, 31.9 (n=46) developed one decompensation event and 22.2% (n=32) developed more than one decompensation events, 7.6 % (n=11) patients were diagnosed with HCC, 16.6 % (n=24) died. On multivariable regression, age 53.3 years (OR 1.64, p<0.005), decompensated cirrhosis (OR 1.91, p<0.001) were associated with significantly higher odds of undergoing surveillance every 4-6 months for liver decompensation and every 12 -14 months for HCC. Close monitoring every 4-6 months (p=0.001) versus every 12-14 months was associated with reduced risk of decompensation. Conclusions. Our study suggests that routine monitoring for patients with delta viral liver cirrhosis is suboptimal. Monitored patients were more likely to prevent decompensation and had significantly better survival. More efforts are needed to optimize the surveillance of patients with delta liver cirrhosis. [ABSTRACT FROM AUTHOR]