학술논문

Alteration of Nitric Oxide Production in Rats Exposed to a Prolonged, Extremely Low-Frequency Magnetic Field.
Document Type
Article
Source
Electromagnetic Biology & Medicine. 2007, Vol. 26 Issue 2, p99-106. 8p. 1 Black and White Photograph, 1 Chart.
Subject
*ELF electromagnetic fields
*NITRIC oxide
*RATS
*BIOLOGICAL systems
*ELECTROMAGNETIC fields
*MAGNETIC fields
Language
ISSN
1536-8378
Abstract
The purpose of this study is to investigate the possible effect of an extremely low-frequency magnetic field (ELF-MF) on nitric oxide (NO) level. In this study, 27 male Sprague-Dawley rats were used. The rats were divided into three groups: two experimental and one control (sham-exposed). The first and second experimental group (n = 10) were exposed to 100 µT and 500 µT ELF-MF during 10 months, 2 h a day, respectively, and the third (n = 7) group was treated like an experimental group except for ELF-MF exposure in methacrylate boxes. After ELF-MF and sham exposure, serum nitrite levels were measured by Griess reaction. A significant reduction was observed in nitrite levels among the first and second experimental groups of rats and sham-exposed rats after exposure for 10 months, 2 h a day, to ELF-MF of 100 and 500 µT (p < 0.01). These results suggest that prolonged ELF-MF exposure at intensities of exposure limits, determined by ICNIRP for public and occupational, may reduce NO production probably affected by NO generation pathways. [ABSTRACT FROM AUTHOR]