부산대학교 도서관

Immune-mediated thrombocytopenia is commonly caused by platelet-reactive antibodies mostly against polymorphic structures residing on platelet glycoproteins such as human leucocyte antigen and human platelet antigen ( HLA class I and HPA). In the Japanese population, some individuals do not express CD36 ( CD36 null also known as Naka) on the cell surface. Immunization of these individuals can lead to the development of CD36 isoantibodies (anti-Naka) which play a role in the mechanism of platelet transfusion refractoriness, post-transfusion purpura and fetal/neonatal alloimmune thrombocytopenia. Until today, however, little is known about the clinical relevance of CD36 deficiency and CD36 isoantibodies among other South-East Asian populations. Therefore, multinational study was organised under the aegis of the ISBT to study the distribution of CD36 deficiency in this region. [ABSTRACT FROM AUTHOR]