학술논문
Immunohistochemical localization of S-100 protein and its subunits in melanotic lesions in the oral mucosa and skin.
Document Type
Journal Article
Author
Source
Subject
*MELANOMA
*TUMORS
*IMMUNOHISTOCHEMISTRY
*NEVUS
*PEPTIDE analysis
*CALCIUM-binding proteins
*CELL nuclei
*CYTOPLASM
*MELANINS
*MOUTH tumors
*ORAL mucosa
*SKIN tumors
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Language
ISSN
0904-2512
Abstract
Immunohistochemical localization of S-100 protein, S-100 a and β subunits was examined in 23 pigmented nevi, 20 malignant melanomas and 8 metastatic melanomas originating from the oral mucosa and skin. Primary oral mucosal melanomas demonstrated no β subunit immunoreactivity while one metastatic lesion from oral melanoma that showed only a small number of melanoma cells reacted with the β subunit. In contrast, most cutaneous melanomas and their metastatic lesions showed immunoreaction with the S-100 β subunit. As for pigmented nevi, immunoreactions with the three antibodies were frequently detected regardless of the site. The differences in the expression of S-100 protein β subunit between cutaneous and mucosal melanomas may be related to differences in inductive interactions between the melanoma cells and the connective tissues in skin and mucosa. [ABSTRACT FROM AUTHOR]