학술논문
Low-dose hypersensitivity of V79 cells under exposure to γ-rays and [sup 4]He ions of different energies: survival and chromosome aberrations.
Document Type
Article
Author
Source
Subject
*CELLS
*GAMMA rays -- Dose-response relationship
*
Language
ISSN
0955-3002
Abstract
Purpose: To examine the low-dose sensitivity of V79 cells under exposure to γ-rays and [sup 4]He ions of different energies. Materials and methods: Cell survival and cytogenetic analysis using the Giemsa technique were studied following irradiation to doses of 0-3 Gy at the INFN-LNL facilities. Results: Low-dose hyper-radiosensitivity (HRS) of V79 was demonstrated after irradiation with γ-rays and α-particles of various linear energy transfers (LET) (58.9, 79.3 and 101.7 keV μm[sup -1]). Cytogenetic analysis showed an LET dependence of aberrations at a dose of 1Gy; the frequency of chromatid fragments appeared to vary with the number of α-particles traversing the cell nucleus. The results of both studies fit together to give a better understanding of so-called 'induced radioresistance' phenomenon. Conclusions: The mechanism of induced cellular radioresistance appears to be initiated after a certain amount of energy is deposited in the cell nucleus. This amount depends on both radiation quality and the number of particles traversing the cell. [ABSTRACT FROM AUTHOR]