부산대학교 도서관

Single cell technologies, lineage tracing mouse models and advanced imaging techniques unequivocally improved the resolution of the cellular landscape of atherosclerosis. Although the discovery of the heterogeneous nature of the cellular plaque architecture has undoubtedly improved our understanding of the specific cellular states in atherosclerosis progression, it also adds more complexity to current and future research and will change how we approach future drug development. In this review, we will discuss how the revolution of new single cell technologies allowed us to map the cellular networks in the plaque, but we will also address current (technological) limitations that confine us to identify the cellular drivers of the disease and to pinpoint a specific cell state, cell subset or cell surface antigen as new candidate drug target for atherosclerosis. [Display omitted] • Single cell omics unveiled the heterogeneous cellular landscape of atherosclerosis. • Intraplaque heterogeneity adds complexity to current and future (drug) research. • Studying cell activation and cell-cell interactions is the next step forward. • More disease and site-specific therapies for atherosclerosis are needed. [ABSTRACT FROM AUTHOR]