학술논문
Smoking as a Risk Factor for Very Late Recurrence in Surgically Resected Early-Stage Primary Hepatocellular Carcinoma.
Document Type
Article
Author
Source
Subject
*PUBLIC health surveillance
*CANCER relapse
*RESEARCH funding
*SMOKING
*EARLY detection of cancer
*RETROSPECTIVE studies
*DESCRIPTIVE statistics
*TUMOR classification
*HEPATOCELLULAR carcinoma
*DISEASE risk factors
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Language
ISSN
1179-5549
Abstract
Background: The risk of first recurrence of hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed to assess the incidence and prognostic factors for very late recurrence among patients who achieved 5 years' recurrence-free survival (RFS) after primary resection. Methods: We retrospectively analyzed 337 patients with early-stage HCC underwent primary tumor resection and achieved more than 5 years' RFS. Results: A total of 77 patients (22.8%) developed very late recurrence. The cumulative very late recurrence rate increased from 6.9% and 11.7% to 16.6% at 6, 7, and 8 years, respectively. Patients stopped smoking had a higher rate of very late RFS. Conclusions: The high rates of very late recurrence in HCC indicate that patients warrant continued surveillance, even after 5 recurrence-free years. Moreover, smoking is a risk factor for very late HCC recurrence, and quitting smoking may reduce the risk of very late recurrence. [ABSTRACT FROM AUTHOR]