학술논문
Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries.
Document Type
Article
Author
Source
Subject
*MULTIPLE organ failure
*SEPSIS
*UROKINASE
*WOUNDS & injuries
*PLASMINOGEN activators
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Language
ISSN
1354-750X
Abstract
Purpose:The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas. Methods:Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset. Results:Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis. Conclusions:suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas. [ABSTRACT FROM PUBLISHER]