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COVID-19, Omicron, SARS-CoV-2, BA.5, subvariant, variants of concern Keywords: BA.5; COVID-19; Omicron; SARS-CoV-2; subvariant; variants of concern EN BA.5 COVID-19 Omicron SARS-CoV-2 subvariant variants of concern 1202 1204 3 10/07/22 20221101 NES 221101 The SARS-CoV-2 B.1.1.529 variant (Omicron) has spread aggressively around the world with rapid transmission in Canada identified within days of its classification as a variant of concern by the World Health Organization.1,2 The BA.5 subvariant in particular has quickly spread to over 50 countries with recent rapid propagation in Central Canada, increasing from 45.8% to 78.2% of all SARS-CoV-2 infections in Ontario in the first half of July.3 Alongside, per cent positivity of testing increased from 8.4% to 14.8%, sufficient for the provincial government to declare a seventh wave driven by BA.5 on the 6th of July (Figure 1).4,5 During the same time period, the Quebec government also reported a seventh wave, with BA.5 representing 75.5% of all SARS-CoV-2 infections in Quebec.6 The predominance of BA.5 in the most densely populated area of Canada indicates yet another pandemic epidemiological shift. A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants. [Extracted from the article]