부산대학교 도서관

Objective:Can gestational weight gain in obese women be restricted by 10-h dietary consultations and does this restriction impact the pregnancy-induced changes in glucose metabolism?Design:A randomized controlled trial with or without restriction of gestational weight gain to 6–7 kg by ten 1-h dietary consultations.Subjects:Fifty nondiabetic nonsmoking Caucasian obese pregnant women were randomized into intervention group (n=23, 28±4 years, prepregnant body mass index (BMI) 35±4 kg m−2) or control group (n=27, 30±5 years, prepregnant BMI 35±3 kg m−2).Measurements:The weight development was measured at inclusion (15 weeks), at 27 weeks, and 36 weeks of gestation. The dietary intakes were reported in the respective weeks by three 7-day weighed food records and blood samples for analyses of fasting s-insulin, s-leptin, b-glucose, and 2-h b-glucose after an oral glucose tolerance test were collected.Results:The women in the intervention group successfully limited their energy intake, and restricted the gestational weight gain to 6.6 kg vs a gain of 13.3 kg in the control group (P=0.002, 95% confidence interval (CI): 2.6–10.8 kg). Both s-insulin and s-leptin were reduced by 20% in the intervention group compared to the control group at week 27, mean difference: −16 pmol l−1 (P=0.04, 95% CI: −32 to −1) for insulin and −23 ng ml−1 (P=0.004, 95% CI: −39 to −8) for leptin. At 36 weeks of gestation, the s-insulin was further reduced by 23%, −25 pmol l−1 (−47 to −4, P=0.022) and the fasting b-glucose were reduced by 8% compared with the control group (−0.3 mmol l−1, −0.6 to −0.0, P=0.03).Conclusions:Restriction of gestational weight gain in obese women is achievable and reduces the deterioration in the glucose metabolism.International Journal of Obesity (2008) 32, 495–501; doi:10.1038/sj.ijo.0803710; published online 29 January 2008 [ABSTRACT FROM AUTHOR]