학술논문
T-cell subset composition and functionality in patients with Waldenström's macroglobulinemia.
Document Type
Letter
Author
Source
Subject
*T cells
*CYTOTOXIC T cells
*IMMUNOGLOBULIN light chains
*B cell lymphoma
*PEARSON correlation (Statistics)
*WALDENSTROM'S macroglobulinemia
*FLUDARABINE
*ANAPLASTIC lymphoma kinase
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Language
ISSN
1042-8194
Abstract
Since WM PB blood T-cells appear to resemble T-cells from HD, we hypothesized this could be due to the lack of interaction with the WM tumor cells that mainly reside in the BM. Waldenström's macroglobulinemia (WM) is an incurable low-grade B-cell non-Hodgkin lymphoma (B-NHL) characterized by bone marrow (BM) infiltration with lymphoplasmacytic cells, and the presence of an IgM paraproteinemia. WM resembles chronic lymphocytic leukemia (CLL) with regard to various biologic and clinical characteristics; both B cell malignancies have an indolent course with low proliferation rates, and a comparable gene expression profile similar to that of peripheral blood (PB) resting B-cells closely related to memory B cells [[3]]. Lymphocyte analysis in PB samples from WM patients (n = 26) HDs (n = 21) and CLL patients (n = 17) and in BM samples from WM patients (n = 10) and HD (n = 10) by flow cytometry. [Extracted from the article]