학술논문
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
Document Type
Journal Article
Author
Source
Subject
*GENETIC mutation
*CHROMOSOME abnormalities
*GENES
*PROTEINS
*BIOMOLECULES
*DISEASES
*CARRIER proteins
*COMPARATIVE studies
*ENZYMES
*GENETIC polymorphisms
*RESEARCH methodology
*MEDICAL cooperation
*MEMBRANE proteins
*PEUTZ-Jeghers syndrome
*RESEARCH
*TRANSCRIPTION factors
*EVALUATION research
*NUCLEAR proteins
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Language
ISSN
0007-0920
Abstract
Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations. [ABSTRACT FROM AUTHOR]