학술논문
Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis.
Document Type
Article
Author
Source
Subject
*KIDNEY failure
*LUPUS nephritis
*TACROLIMUS
*DRUG administration
*CREATININE
*PATIENTS
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Language
ISSN
0049-8254
Abstract
1. The purpose of the present study was to investigate the effect of tacrolimus concentration in blood 12 h after administration (C12h) on acute renal dysfunction in patients with lupus nephritis (LN) taking tacrolimus once daily. 2. Five of the 35 LN patients experienced tacrolimus-induced acute renal dysfunction. 3. The average annualC12hof tacrolimus was higher for patients with events of elevated serum creatinine level than for patients not experiencing these events [6.4 (5.6–8.8) versus 2.8 (2.2–4.6) ng/mL, respectively,p = 0.001]. 4. The average annual tacrolimusC12hwas higher for patients withCYP3A5*3/*3(PM) than for patients with theCYP3A5*1allele (EM) [4.6 (3.2–6.6) versus 2.5 (2.0–3.1) ng/mL, respectively,p = 0.002]. 5. The area under the receiver operating characteristic was 0.887, which gave the best sensitivity (80.0%) and specificity (86.7%) at a tacrolimusC12h(average annualC12horC12hat events) threshold of 5.2 ng/mL. 6.C12hmeasurements,CYP3A5genotyping and dose adjustments of tacrolimus should be performed to prevent acute renal dysfunction in LN patients taking tacrolimus once daily. [ABSTRACT FROM AUTHOR]