학술논문
Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia.
Document Type
Journal Article
Author
Source
Subject
*NUCLEOSIDES
*HIV-positive persons
*PORTAL hypertension
*LIVER failure
*MITOCHONDRIAL pathology
*DRUG side effects
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Language
ISSN
0140-6736
Abstract
Acute hepatitis with lactic acidosis is a life-threatening but reversible toxic effect on mitochondria of HIV-1 nucleoside-analogue treatment. We report fatal portal hypertension, liver failure, and persistent mitochondrial dysfunction in a man aged 65 years with HIV-1 infection who had recovered from nucleoside-analogue-induced acute hepatitis and lactic acidaemia more than 18 months previously. We believe that symptom free patients who receive nucleoside-analogue therapy should have hepatic function constantly monitored, especially those with past or present lactic acidaemia. [ABSTRACT FROM AUTHOR]