학술논문
Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis.
Document Type
Article
Author
Lococo, Filippo; Nachira, Dania; Chiappetta, Marco; Evangelista, Jessica; Falcoz, Pierre Emmanuel; Ruffini, Enrico; Van Schil, Paul; Scarci, Marco; Furàk, Jòzsef; Sollitto, Francesco; Guerrera, Francesco; Spaggiari, Lorenzo; Aigner, Clemens; Evangelia, Liverakou; Billè, Andrea; Moser, Bernhard; Thomas, Pascal Alexandre; Liberman, Moishe; Boubia, Souheil; Campisi, Alessio
Source
Subject
*MYASTHENIA gravis
*THYMECTOMY
*CARCINOMA
*RADIOTHERAPY
*EPITHELIAL tumors
*MUSCLE weakness
*SURVIVAL rate
*DATABASES
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Language
ISSN
2075-4418
Abstract
Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients. [ABSTRACT FROM AUTHOR]