학술논문
Diagnosis and management of aspergillosis in the Netherlands: a national survey.
Document Type
Article
Author
Lestrade, Pieter P. A.; Meis, Jacques F.; Arends, Jan P.; Beek, Martha T.; Brauwer, Els; Dijk, Karin; Greeff, Sabine C.; Haas, Pieter‐Jan; Hodiamont, Caspar J.; Kuijper, Ed J.; Leenstra, Tjalling; Muller, Anouk E.; Oude Lashof, Astrid M. L.; Rijnders, Bart J.; Roelofsen, Eveline; Rozemeijer, Wouter; Tersmette, Mathijs; Terveer, Elizabeth M.; Verduin, Cees M.; Wolfhagen, Maurice J. H. M.
Source
Subject
*ASPERGILLOSIS
*MOLECULAR structure of azoles
*VORICONAZOLE
*WOLMAN disease
*AMPHOTERICIN B
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Language
ISSN
0933-7407
Abstract
A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers ( UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B. [ABSTRACT FROM AUTHOR]