학술논문
Biotransformation novel advances – 2021 year in review.
Document Type
Article
Author
Khojasteh, S. Cyrus; Argikar, Upendra A.; Cho, Sungjoon; Crouch, Rachel; Heck, Carley J. S.; Johnson, Kevin M.; Kalgutkar, Amit S.; King, Lloyd; Maw, Hlaing; Seneviratne, Herana Kamal; Wang, Shuai; Wei, Cong; Zhang, Donglu; Jackson, Klarissa D.; Kramlinger, Valerie M.; Dalvie, Deepak; O'Neill, James; Su, Dian; Teitelbaum, Aaron M.; Totah, Rheem A.
Source
Subject
*BIOCONVERSION
*DRUG discovery
*MOLECULAR structure
*DRUG development
*
*
*
Language
ISSN
0360-2532
Abstract
Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (2022) nicely captures the future (and the past) of highly impactful science of biotransformation (see the first article). Based on the selected articles, this review was categorized into three sections: (1) new modalities biotransformation, (2) drug discovery biotransformation, and (3) drug development biotransformation (Table 1). [ABSTRACT FROM AUTHOR]