학술논문
Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.
Document Type
Article
Author
Ramiro, Iris Bea L.; Bjørn-Yoshimoto, Walden E.; Imperial, Julita S.; Gajewiak, Joanna; Salcedo, Paula Flórez; Watkins, Maren; Taylor, Dylan; Resager, William; Ueberheide, Beatrix; Bräuner-Osborne, Hans; Whitby, Frank G.; Hill, Christopher P.; Martin, Laurent F.; Patwardhan, Amol; Concepcion, Gisela P.; Olivera, Baldomero M.; Safavi-Hemami, Helena
Source
Subject
*CONOTOXINS
*CONUS
*VENOM
*SOMATOSTATIN
*MEDICAL sciences
*LIFE sciences
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Language
ISSN
2375-2548
Abstract
The article offers information about the somatostatin (SS) venom analogs evolved by fish-hunting cone snails. It mentions that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. It discusses the model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.