학술논문
SCHIZOPHRENIA AND POLYMORPHIC CAG REPEATS ARRAY OF CALCIUM-ACTIVATED POTASSIUM CHANNEL ( KCNN3 ) GENE IN SERBIAN POPULATION.
Document Type
Article
Author
Source
Subject
*SCHIZOPHRENIA
*PSYCHOSES
*PATHOLOGICAL psychology
*CALCIUM
*POTASSIUM
*GENES
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Language
ISSN
0020-7454
Abstract
KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population. [ABSTRACT FROM AUTHOR]