부산대학교 도서관

Following Hardy-Weinberg disequilibrium (HWD) occurring at a single locus and linkage disequilibrium (LD) between two loci in generations, we here proposed the third genetic disequilibrium in a population: recombination disequilibrium (RD). RD is a measurement of crossover interference among multiple loci in a random mating population. In natural populations besides recombination interference, RD may also be due to selection, mutation, gene conversion, drift and/or migration. Therefore, similarly to LD, RD will also reflect the history of natural selection and mutation. In breeding populations, RD purely results from recombination interference and hence can be used to build or evaluate and correct a linkage map. Practical examples from F 2 , testcross and human populations indeed demonstrate that RD is useful for measuring recombination interference between two short intervals and evaluating linkage maps. As with LD, RD will be important for studying genetic mapping, association of haplotypes with disease, plant breading and population history. • Recombination disequilibrium (RD) was proposed in a way similar to linkage disequilibrium • A statistical test for RD in F2 population and natural population was given • Like Hardy-Weinberg disequilibrium and linkage disequilibrium, RD was also a genetic disequilibrium • In nature population RD may also result from selection, mutation, drift, and gene conversion • RD can be applied to do fine genetic mapping and correct associations of haplotypes with disease of study [ABSTRACT FROM AUTHOR]