학술논문
The contribution of MYC and PLK1 expression to proliferative capacity in diffuse large B-cell lymphoma.
Document Type
Article
Author
Source
Subject
*LYMPHOMAS
Language
ISSN
1042-8194
Abstract
Polo-like kinase-1 (PLK1) regulates the MYC-dependent kinome in aggressive B-cell lymphoma. However, the role of PLK1 and MYC toward proliferation in diffuse large B-cell lymphoma (DLBCL) is unknown. We use multiplexed fluorescent immunohistochemistry (fIHC) to evaluate the co-localization of MYC, PLK1 and Ki67 to study their association with proliferation in DLBCL. The majority (98%, 95% CI 95–100%) of MYC/PLK1-double positive tumor cells expressed Ki67, underscoring the key role of the MYC/PLK1 circuit in proliferation. However, only 38% (95% CI 23–40%) and 51% (95% CI 46–51%) of Ki67-positive cells expressed MYC and PLK1, respectively. Notably, 40% (95% CI 26–43%) of Ki67-positive cells are MYC- and PLK-negative. A stronger correlation exists between PLK1 and Ki67 expression (R = 0.74, p <.001) than with MYC and Ki67 expression (R = 0.52, p <.001). Overall, the results indicate that PLK1 has a higher association than MYC in DLBCL proliferation and there are mechanisms besides MYC and PLK1 influencing DLBCL proliferation. [ABSTRACT FROM AUTHOR]