학술논문
Keep-ING balance: Tumor suppression by epigenetic regulation.
Document Type
Article
Author
Source
Subject
*DNA repair
*EPIGENETICS
*GENE silencing
*GENE expression
*NEOPLASTIC cell transformation
*CANCER cell differentiation
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Language
ISSN
0014-5793
Abstract
Cancer cells accumulate genetic and epigenetic changes that alter gene expression to drive tumorigenesis. Epigenetic silencing of tumor suppressor, cell cycle, differentiation and DNA repair genes contributes to neoplastic transformation. The ING (inhibitor of growth) proteins (ING1-ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 - and several HAT chromatin-modifying complexes. This review will describe the characteristic pathways by which ING family proteins differentially affect the Hallmarks of Cancer and highlight the various epigenetic mechanisms by which they regulate gene expression. Finally, we will discuss their potentials as biomarkers and therapeutic targets in epigenetic treatment strategies. [ABSTRACT FROM AUTHOR]