학술논문
Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report.
Document Type
Article
Author
Source
Subject
*ASTHMA diagnosis
*ASTHMA prevention
*AUTOIMMUNE disease prevention
*ADDISON'S disease
*AUTOIMMUNE diseases
*AUTOIMMUNE thyroiditis
*THORACIC surgery
*CHRONIC active hepatitis
*IMMUNOSUPPRESSIVE agents
*MYASTHENIA gravis
*DISEASE progression
*THYMOMA
*PREDNISOLONE
*DISEASE complications
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Language
ISSN
1472-6823
Abstract
Background: Autoimmune polyglandular syndrome type 2 (APS-2) is a rare and complex clinical entity, and little is known about its etiology and progression. Case presentation: A 52-year-old woman with autoimmune hepatitis (AIH) and bronchial asthma was diagnosed with APS-2; autoimmune Addison's disease (AD), and Hashimoto's thyroiditis (HT), and she underwent prednisolone (PSL) treatment. Five months later, she presented ptosis and was diagnosed with thymoma-associated myasthenia gravis (MG). Thymectomy and PSL treatment with immuno-suppressants appeared to ameliorate MG, AD, AIH, HT, and bronchial asthma. HLA typing analysis revealed that the patient had susceptible HLA alleles to MG, AIH, and HT in a Japanese population. Conclusions: This case suggests common endocrinological and autoimmune aspects of APS-2 and AIH with thymoma-associated MG, which are considered to be extremely rare complications. [ABSTRACT FROM AUTHOR]