학술논문
Novel antifungal agents: Triazolopyridines as inhibitors of β-1,6-glucan synthesis
Document Type
Article
Author
Source
Subject
*ANTIFUNGAL agents
*ENZYMES
*CHEMICAL synthesis
*ANTIDEPRESSANTS
*IMIDAZOPYRIDINES
*FUNGAL cell walls
*CANDIDA
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Language
ISSN
0968-0896
Abstract
Abstract: Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of β-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species. [ABSTRACT FROM AUTHOR]