학술논문
Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout.
Document Type
Article
Author
Source
Subject
*TYPE 1 diabetes
*PANCREATIC beta cells
*TOXIN receptors
*HYPERGLYCEMIA
*LABORATORY mice
*XENOGRAFTS
*HOMOGRAFTS
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Language
ISSN
0006-291X
Abstract
Highlights: [•] Novel transgenic mouse models for T1D were established by TRECK method. [•] They were established on C57BL/6 and SCID background. [•] DT administration resulted severe ablation of pancreatic β cells within 3days. [•] Hyperglycemia of SCID-Tg mice is cured by allogeneic and xenogeneic transplantation. [•] These Tg mice are highly useful for diabetogenic research. [ABSTRACT FROM AUTHOR]