학술논문
Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma.
Document Type
Article
Author
Ganly, Ian; Liu, Eric Minwei; Fengshen Kuo; Makarov, Vladimir; Yiyu Dong; Jinsung Park; Yongxing Gong; Gorelick, Alexander N.; Knauf, Jeffrey A.; Benedetti, Elisa; Tait-Mulder, Jacqueline; Morris, Luc G. T.; Fagin, James A.; Intlekofer, Andrew M.; Krumsiek, Jan; Gammage, Payam A.; Ghossein, Ronald; Bin Xu; Chan, Timothy A.; Reznik, Ed
Source
Subject
*MITOCHONDRIAL DNA
*CITRATES
*FATTY acid synthases
*HYDROPHILIC interaction liquid chromatography
*LABORATORY management
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Language
ISSN
2375-2548
Abstract
The article focuses on Hürthle cell carcinomas (HCCs) display two exceptional genotypes: near-homoplasmic mutation of mitochondrial DNA (mtDNA) and genome-wide loss of heterozygosity (gLOH). It mentions mtDNA mutations and profound depletion of citrate pools are common in HCC and other thyroid malignancies, suggesting that thyroid cancers are broadly equipped to survive tricarboxylic acid cycle impairment.