학술논문

Plexiform Fibromyxoma in the Stomach: Immunohistochemical Profile and Comprehensive Genetic Characterization.
Document Type
Article
Source
International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p4847. 8p.
Subject
*FIBROMAS
*GASTROINTESTINAL stromal tumors
*STOMACH
*LUNG cancer
Language
ISSN
1661-6596
Abstract
Plexiform fibromyxoma (PF), also referred to as plexiform angiomyxoid myofibroblast tumor, is an exceedingly rare mesenchymal neoplasm primarily affecting the stomach. Herein, we present a case of PF diagnosed in a 71-year-old male with a history of lung cancer, initially suspected to have a gastrointestinal stromal tumor (GIST) of the stomach, who subsequently underwent subtotal gastrectomy. The histopathological and molecular features of the tumor, including mutations in ABL1, CCND1, CSF1R, FGFR4, KDR, and MALAT1-GLI1 fusion, are elucidated and discussed in the context of diagnostic, prognostic, and therapeutic considerations. [ABSTRACT FROM AUTHOR]