학술논문
Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018.
Document Type
Journal Article
Author
Sridhar, Siddharth; Cheng, Vincent C. C.; Shuk-Ching Wong; Yip, Cyril C. Y.; Shusheng Wu; Lo, Anthony W. I.; Kit-Hang Leung; Mak, Winger W. N.; Jianpiao Cai; Xin Li; Chan, Jasper F. W.; Lau, Susanna K. P.; Woo, Patrick C. Y.; Wai-Ming Lai; Tze-Hoi Kwan; Au, Timmy W. K.; Chung-Mau Lo; Wong, Sally C. Y.; Kwok-Yung Yuen; Wong, Shuk-Ching
Source
Subject
*HEPATITIS E virus
*VIRUS diseases
*GENOTYPES
*LIVER function tests
*PORTAL hypertension
*HEMAPHERESIS
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Language
ISSN
1080-6040
Abstract
Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients. [ABSTRACT FROM AUTHOR]