학술논문
Synthesis and Cytotoxicity of Epiandrosterone Hydrazones.
Document Type
Article
Author
Source
Subject
*HYDRAZONES
*HYDRAZONE derivatives
*STRUCTURE-activity relationships
*CELL lines
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Language
ISSN
0009-3130
Abstract
Two series of hydrazones were synthesized from 3β-hydroxy- and 3β-(1-adamantoate)-5α-androstan-17- one, respectively, to study the structure–activity relationship. Cytotoxicity studies showed that 5α-androstan- 3β-ol-17-one m-nitrobenzoylhydrazone exhibited pronounced specific activity in a Hoechst experiment against lung carcinoma (A-549) and colorectal adenocarcinoma cell lines (DLD-1). [ABSTRACT FROM AUTHOR]