학술논문
Deltamethrin-induced alteration of iron metabolism in Wistar rats.
Document Type
Article
Source
Subject
*LYMPHOCYTE count
*IRON metabolism
*BLOOD proteins
*RATS
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Language
ISSN
0277-2248
Abstract
The impact of sub-lethal exposure to deltamethrin on the expression of hepcidin, ferroportin and transferrin genes in Wistar rats was studied. A dosage of 30 mg/kg per day for five days was found to modify the hepcidin-ferroportin axis that primarily governs iron homeostasis. Significant variations in erythrocyte, leukocyte, lymphocyte, platelet and monocyte counts, as well as the reduced serum protein profile, suggested anemia. The results collectively demonstrated the novel finding of deltamethrin's disruptive effect on iron homeostasis. [ABSTRACT FROM AUTHOR]