학술논문
BAG6 Variant rs805303 is Nominally Associated with ACEi-induced Cough Among Filipinos.
Document Type
Article
Author
Reganit, Paul Ferdinand M.; Nevado Jr., Jose B.; Cutiongco - de la Paz, Eva Maria C.; Taquiso, Jezreel L.; L. Aman, Aimee Yvonne Criselle; Llanes, Elmer Jasper B.; Magno, Jose Donato A.; Ona, Deborah Ignacia D.; Punzalan, Felix Eduardo R.; Santos, Lourdes Ella G.; Tiongco II, Richard Henry P.; Aherrera, Jaime M.; Abrahan IV, Lauro L.; Agustin, Charlene F.; Bejarin, Adrian John P.; Sy, Rody G.
Source
Subject
*COUGH
*FENTANYL
*ACE inhibitors
*MULTIPLE regression analysis
*FILIPINOS
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Language
ISSN
0031-7683
Abstract
Cough is a common side effect of angiotensin converting enzyme inhibitor (ACEi) therapy. The incidence of ACEi-induced cough has been shown to correlate with genetic variation among different populations. This study aimed to determine the association of candidate genetic polymorphisms with ACEi-induced cough among Filipinos. Two hundred twenty (220) participants on ACEi therapy pressure-lowering in an unmatched case-control study (82 cases with ACEiinduced cough and 138 controls). Genomic DNA samples were extracted and genotyped for selected genetic variants. The association of genetic variants and clinical factors with ACEi-induced cough was determined using regression analyses. Univariate logistic regression showed that the BAG6 variant rs805303 is nominally associated with ACEi-induced cough among Filipinos, at a percomparison error rate (PCER) of 0.05 (OR 2.10, p = 0.016). The association of the variant with ACEi cough was statistically significant after multiple regression analysis (adjusted OR 2.09, p = 0.022) while adjusting for confounding clinical factors (sex, alcohol intake, and diastolic blood pressure). Further studies are needed to validate these findings. [ABSTRACT FROM AUTHOR]