학술논문
Syncytin-1, syncytin-2 and suppressyn in human health and disease.
Document Type
Article
Author
Source
Subject
*HUMAN endogenous retroviruses
*GESTATIONAL trophoblastic disease
*HUMAN physiology
*CLINICAL medicine
*MOLAR pregnancy
*PREECLAMPSIA
*MULTIPLE sclerosis
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Language
ISSN
0946-2716
Abstract
In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products—syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described. [ABSTRACT FROM AUTHOR]