학술논문
Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia.
Document Type
Case Study
Source
Subject
*HYPERCALCEMIA
*PEMBROLIZUMAB
*RESPIRATORY insufficiency
*PROGRAMMED cell death 1 receptors
*PROGRAMMED death-ligand 1
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Language
ISSN
2090-6641
Abstract
PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury and hypoxic respiratory failure that was responsive to corticosteroids suggestive of immunotoxicity from pembrolizumab. [ABSTRACT FROM AUTHOR]