학술논문
At-Home Foscarnet Administration in Patients with Cytomegalovirus Infection Post-Allogeneic Stem Cell Transplantation: A Unicentric, Safe, and Feasible Program.
Document Type
Article
Author
Ruiz-Boy, Sonia; Pedraza, Alexandra; Prat, Marta; Salas, Maria Queralt; Carcelero, Esther; Riu-Viladoms, Gisela; Suárez-Lledó, María; Monge-Escartín, Inés; Rodríguez-Lobato, Luis Gerardo; Martínez-Roca, Alexandra; Rovira, Montserrat; Martínez, Carmen; Gallego, Cristina; Urbano-Ispizua, Álvaro; Sánchez, Joan; Marcos, María Ángeles; Fernández-Avilés, Francesc
Source
Subject
*STEM cell transplantation
*CYTOMEGALOVIRUS diseases
*DRUG efficacy
*HOSPITAL administration
*HOSPITAL patients
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Language
ISSN
1424-8247
Abstract
Cytomegalovirus (CMV) infection is a relevant cause of morbimortality in patients receiving allogeneic stem cell transplantation (allo-HCT). Foscarnet (FCN) is an effective drug against CMV administered intravenously and usually on an inpatient basis. The Home Care Unit (HCU) for hematologic patients at our hospital designed an at-home FCN administration model to avoid the hospitalization of patients requiring FCN treatment. This study analyzes whether the at-home administration of FCN is as safe and effective as its hospital administration. We collected and compared demographic, clinical, analytical, and economic data of patients with CMV infection post-allo-HCT who received FCN in the hospital (n = 16, 17 episodes) vs. at-home (n = 67, 88 episodes). The proportions of patients with cured CMV infections were comparable between the two groups (65.9% vs. 76.5%, p = 0.395). The median duration of FCN treatment was 15 (interquartile range [IQR] 9–23) and 14 (IQR 11–19) days in the HCU and inpatient cohorts, respectively (p = 0.692). There were no significant differences in the FCN toxicities between groups except for hypocalcemia (26.1% vs. 58.8%, p = 0.007), which was more prevalent in the inpatient cohort. A significant cost-effectiveness was found in the HCU cohort, with a median savings per episode of EUR 5270. It may be concluded that home administration of FCN is a safe, effective, and cost-efficient therapeutic option for patients with CMV infection and disease. [ABSTRACT FROM AUTHOR]