학술논문
Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin–protein conjugates.
Document Type
Article
Author
Source
Subject
*UBIQUITIN
*UBIQUITINATION
*CHEMICAL peel
*PROTEIN stability
*BIOCONJUGATES
*PROTEIN-protein interactions
*CELLULAR signal transduction
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Language
ISSN
1367-5931
Abstract
Covalent attachment of ubiquitin, a process termed ubiquitination, affects the location, function, and stability of modified proteins. Significant advances have been made in building synthetic ubiquitin–protein conjugates that can be used to investigate how ubiquitin regulates diverse biological processes. Herein we describe recent advances and discuss how chemical methods have been implemented to address the molecular underpinnings of ubiquitin-dependent cellular signaling. [ABSTRACT FROM AUTHOR]