학술논문
A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions.
Document Type
Case Study
Author
Donzelli, Sara; Cioce, Mario; Sacconi, Andrea; Zanconato, Francesca; Daralioti, Theodora; Goeman, Frauke; Orlandi, Giulia; Di Martino, Simona; Fazio, Vito Michele; Alessandrini, Gabriele; Telera, Stefano; Carosi, Mariantonia; Ciliberto, Gennaro; Botti, Claudio; Strano, Sabrina; Piccolo, Stefano; Blandino, Giovanni
Source
Subject
*METASTATIC breast cancer
*FIBROBLAST growth factor 2
*
Language
ISSN
1476-4598
Abstract
B. PI3K pathway-related genes were significantly upregulated in PIK3CA- mutated brain metastasis PDO cultures compared to in PIK3CA wild-type brain metastases. Keywords: Breast cancer metastases; Organoids; Alpelisib; PIK3CA mutations EN Breast cancer metastases Organoids Alpelisib PIK3CA mutations 1 7 7 07/26/22 20220722 NES 220722 Sara Donzelli and Mario Cioce contributed equally to this work. A. PI3K pathway-related genes were significantly upregulated in PIK3CA -mutated brain metastases compared to PIK3CA wild-type brain metastases. [Extracted from the article]