학술논문
Characteristics and Outcomes of Patients with Acute Coronary Syndrome and COVID-19.
Document Type
Article
Author
Milovančev, Aleksandra; Petrović, Milovan; Popadić, Višeslav; Miljković, Tatjana; Klašnja, Slobodan; Djuran, Predrag; Ilić, Aleksandra; Kovačević, Mila; Stojšić Milosavljević, Anastazija; Brajković, Milica; Crnokrak, Bogdan; Memon, Lidija; Milojević, Ana; Todorović, Zoran; Čanković, Milenko; Lukić Šarkanović, Mirka; Bjelić, Snežana; Tadić, Snežana; Redžek, Aleksandar; Zdravković, Marija
Source
Subject
*ACUTE coronary syndrome
*COVID-19
*TREATMENT effectiveness
*AORTIC valve insufficiency
*HEART failure
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Language
ISSN
2077-0383
Abstract
Acute coronary syndrome (ACS) in patients with COVID-19 is triggered by various mechanisms and can significantly affect the patient's further treatment and prognosis. The study aimed to investigate the characteristics, major complications, and predictors of mortality in COVID-19 patients with ACS. All consecutive patients hospitalized from 5 July 2020 to 5 May 2021 for ACS with confirmed SARS-Co-2 were prospectively enrolled and tracked for mortality until 5 June 2021. Data from the electronic records for age and diagnosis, matched non-COVID-19 and COVID-19 ACS group, were extracted and compared. Overall, 83 COVID-19 ACS patients, when compared to 166 non-COVID ACS patients, had significantly more prevalent comorbidities, unfavorable clinical characteristics on admission (acute heart failure 21.7% vs. 6.6%, p < 0.01) and higher rates of major complications, 33.7% vs. 16.8%, p < 0.01, and intrahospital 30-day mortality, 6.7% vs. 26.5%, p < 0.01. The strongest predictors of mortality were aortic regurgitation, HR 9.98, 95% CI 1.88; 52.98, p < 0.01, serum creatinine levels, HR 1.03, 95% CI 1.01; 1.04, p < 0.01, and respiratory failure therapy, HR 13.05, 95% CI 3.62; 47.01, p < 0.01. Concomitant ACS and COVID-19 is linked to underlying comorbidities, adverse presenting features, and poor outcomes. Urgent strategies are needed to improve the outcomes of these patients. [ABSTRACT FROM AUTHOR]