학술논문
Completing the Picture—Capturing the Resistome in Antibiotic Clinical Trials.
Document Type
Article
Author
Source
Subject
*ANTIBIOTICS
*CLINICAL trials
*HUMAN microbiota
*DRUG resistance in microorganisms
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Language
ISSN
1058-4838
Abstract
Despite the accepted dogma that antibiotic use is the largest contributor to antimicrobial resistance (AMR) and human microbiome disruption, our knowledge of specific antibiotic-microbiome effects remains basic. Detection of associations between new or old antimicrobials and specific AMR burden is patchy and heterogeneous. Various microbiome analysis tools are available to determine antibiotic effects on microbial communities in vivo. Microbiome analysis of treatment groups in antibiotic clinical trials, powered to measure clinically meaningful endpoints would greatly assist the antibiotic development pipeline and clinician antibiotic decision making. [ABSTRACT FROM AUTHOR]