학술논문
Labor market affiliation of patients with myeloproliferative neoplasms: a population-based matched cohort study.
Document Type
Article
Author
Svingel, Lise Skovgaard; Christensen, Sarah Friis; Kjærsgaard, Anders; Stenling, Anna; Paulsson, Björn; Andersen, Christen Lykkegaard; Christiansen, Christian Fynbo; Stentoft, Jesper; Starklint, Jørn; Severinsen, Marianne Tang; Clausen, Mette Borg; Hilsøe, Morten Hagemann; Hasselbalch, Hans Carl; Frederiksen, Henrik; Bak, Marie; Mikkelsen, Ellen Margrethe
Source
Subject
*CANCER patient psychology
*THROMBOCYTOSIS
*POLYCYTHEMIA vera
*EMPLOYMENT of people with disabilities
*SCIENTIFIC observation
*CONFIDENCE intervals
*MYELOFIBROSIS
*RESEARCH methodology
*MYELOPROLIFERATIVE neoplasms
*COMPARATIVE studies
*DESCRIPTIVE statistics
*PENSIONS
*LABOR market
*LONGITUDINAL method
*DISEASE complications
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Language
ISSN
0284-186X
Abstract
Background: Patients with myeloproliferative neoplasms (MPNs) suffer from substantial symptoms and risk of debilitating complications, yet observational data on their labor market affiliation are scarce. Material and methods: We conducted a descriptive cohort study using data from Danish nationwide registries, including patients diagnosed with MPN in 2010-2016. Each patient was matched with up to ten comparators without MPN on age, sex, level of education, and region of residence. We assessed pre- and post-diagnosis labor market affiliation, defined as working, unemployed, or receiving sickness benefit, disability pension, retirement pension, or other health-related benefits. Labor market affiliation was assessed weekly from two years pre-diagnosis until death, emigration, or 31 December 2018. For patients and comparators, we reported percentage point (pp) changes in labor market affiliation crosssectionally from week - 104 pre-diagnosis to week 104 post-diagnosis. Results: The study included 3,342 patients with MPN and 32,737 comparators. From two years prediagnosis until two years post-diagnosis, a larger reduction in the proportion working was observed among patients than comparators (essential thrombocythemia: 10.2 [95% CI: 6.3-14.1] vs. 6.8 [95% CI: 5.5-8.0] pp; polycythemia vera: 9.6 [95% CI: 5.9-13.2] vs. 7.4 [95% CI: 6.2-8.7] pp; myelofibrosis: 8.1 [95% CI: 3.0-13.2] vs. 5.8 [95% CI: 4.2-7.5] pp; and unclassifiable MPN: 8.0 [95% CI: 3.0-13.0] vs. 7.4 [95% CI: 5.7-9.1] pp). Correspondingly, an increase in the proportion of patients receiving sickness benefits including other health-related benefits was evident around the time of diagnosis. Conclusion: Overall, we found that Danish patients with essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN had slightly impaired labor market affiliation compared with a population of the same age and sex. From two years pre-diagnosis to two years post-diagnosis, we observed a larger reduction in the proportion of patients with MPN working and a greater proportion receiving sickness benefits compared with matched individuals. [ABSTRACT FROM AUTHOR]