부산대학교 도서관

Transthyretin cardiac amyloidosis (ATTR) is a protein deposition disease characterized by deposition of amyloid especially in the myocardium, altering its function. Diagnosing this pathology represents a challenge for the physician mainly because the reasons for hospitalization could be common for more than one disease. If cardiac amyloidosis is suspected and endomyocardial biopsy (the gold standard method) is not an option, the physician must resort to alternative diagnostic methods. We present the case of a patient suspected of cardiac amyloidosis based on the electrocardiography and echocardiography results for which imaging investigations (cardiac MRI and bisphosphonate scintigraphy) were the solution. The diagnosis of ATTR was made after the patient had underwent 99mTc-HDP bone scan. In order to determine the ATTR type involved, the patient performed genetic testing. Conclusion: For patients in whom endomyocardial biopsy is not an option, bone scintigraphy may provide important data for ATTR cardiac amyloidosis diagnosis. Therefore, it should be included in the diagnostic protocol and in the multidisciplinary precision approach of patients suspected of this pathology. [ABSTRACT FROM AUTHOR]