학술논문
Wnt/beta-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer.
Document Type
Article
Author
Source
Subject
*CATENINS
*WNT proteins
*KAPLAN-Meier estimator
*MULTIVARIATE analysis
*LOG-rank test
OVARIAN cancer patients
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Language
ISSN
1757-2215
Abstract
Background β-catenin is the key protein in the WNT signalling pathway and it forms adherent junctions together with E-cadherin. In ovarian carcinoma, abnormal expression of β-catenin, Ecadherin and WNT-1 was observed, but their prognostic and predictive role is unclear. The aim of this study was to clarify the prognostic and predictive role of E-cadherin, β-catenin and WNT-1 in advanced epithelial ovarian carcinoma (AEOC). Methods The expression of E-cadherin, β-catenin and WNT-1 was determined by immunohistochemistry in AEOC. The correlation between expression of these proteins and progression-free survival (PFS) and overall survival (OS) was evaluated. Statistical analyses included Kaplan-Meier estimation, log-rank test, Spearman correlation and Cox proportionalhazards model. Results In ovarian cancer, intense expression of E-cadherin, β-catenin and WNT-1 was found. In multivariate analysis, strong membrane β-catenin expression was an independent unfavourable predictor for PFS (HR 2.19, 95% CI 1.09-4.39; p = 0.028), while in univariate analysis, strong membrane β-catenin expression was a prognostic factor for OS in patients with AOC (p = 0.039). In multivariate analysis, only resistance to first-line chemotherapy was an adverse independent prognostic factor for OS (HR 16.84; 95% CI 5.07-55.98; p < 0.0001). Additionally, strong membranous β-catenin expression was associated with resistance to platinum-based chemotherapy (p = 0.027). Conclusions These findings support that WNT/β-catenin pathway and E-cadherin are important factors in advanced epithelial ovarian cancer. [ABSTRACT FROM AUTHOR]