부산대학교 도서관

The actin cortex is an active adaptive material, embedded with complex regulatory networks that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range of dynamic behaviours, from generating pulsatory contractions and travelling waves to forming organised structures. Despite the progress in characterising the biochemical and mechanical components of the actin cortex, the emergent dynamics of this mechanochemical system is poorly understood. Here we develop a reaction-diffusion model for the RhoA signalling network, the upstream regulator for actomyosin assembly and contractility, coupled to an active actomyosin gel, to investigate how the interplay between chemical signalling and mechanical forces regulate stresses and patterns in the cortex. We demonstrate that mechanochemical feedback in the cortex acts to destabilise homogeneous states and robustly generate pulsatile contractions. By tuning active stress in the system, we show that the cortex can generate propagating contraction pulses, form network structures, or exhibit topological turbulence. Author summary: The cellular actin cortex is a dynamic sub-membranous network of filamentous actin, myosin motors, and other accessory proteins that regulates the ability of cells to maintain or change shapes. While the key molecular components and mechanical properties of the actin cortex have been characterized, the ways in which biochemical signalling and mechanical forces interact to regulate cortex behaviours remain poorly understood. In this article, we develop a mathematical model for the actomyosin cortex that combines the reaction-diffusion dynamics of signalling proteins with active force generation by actomyosin networks. Using this model, we investigate how the feedback between mechanics and biochemical signalling regulate the propagation of actomyosin flows, mechanical stresses, and pattern formation in the cortex. Our work reveals a variety of ways in which the cortex can tune the dynamic coupling between biochemical activity, force production, and advective transport to control mechanical behaviours. [ABSTRACT FROM AUTHOR]