학술논문
Trajectories of CD4 + /CD8 + T-Cells Ratio 96 Weeks after Switching to Dolutegravir-Based Two-Drug Regimens: Results from a Multicenter Prospective Cohort Study.
Document Type
Article
Author
Taramasso, Lucia; Falletta, Antonio; Ricci, Elena; Orofino, Giancarlo; Squillace, Nicola; Menzaghi, Barbara; De Socio, Giuseppe Vittorio; Molteni, Chiara; Pellicanò, Giovanni Francesco; Gulminetti, Roberto; Madeddu, Giordano; Sarchi, Eleonora; Vichi, Francesca; Celesia, Benedetto Maurizio; Bonfanti, Paolo; Di Biagio, Antonio
Source
Subject
*T cells
*CD4 antigen
*LAMIVUDINE
*LONGITUDINAL method
*COHORT analysis
*RALTEGRAVIR
*EMTRICITABINE
*PROTEASE inhibitors
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Language
ISSN
1999-4915
Abstract
The aim of the present study was to evaluate CD4/CD8 dynamics in patients on dolutegravir (DTG)-based two-drug regimens (2DRs) and compare them with DTG-containing triple-drug regimens (3DRs). A prospective observational study was performed in the context of the SCOLTA cohort. Experienced PWH with HIV-RNA < 50 copies/mL were included if they were on the DTG-2DR, the DTG + tenofovir/emtricitabine (TDF/FTC) regimen, the DTG + tenofovir alafenamide (TAF)/FTC regimen, or the DTG + abacavir/lamivudine (ABC/3TC) regimen; they were followed-up for at least one year. A total of 533 PWH were enrolled, 120 in the DTG + 3TC group, 38 in the DTG + protease inhibitors (PI) group, 67 in the DTG + rilpivirine (RPV) group, 49 in the DTG + TDF/FTC group, 27 in the DTG + TAF/FTC group, and 232 in the DTG + ABC/3TC group. After one year, the CD4/CD8 ratio significantly increased in the PWH treated with DTG + 3TC (+0.08 ± 0.26), DTG + TDF/FTC (+0.1 ± 0.19), and DTG + ABC/3TC (+0.08 ± 0.25). At two years, the CD4/CD8 increase was confirmed for PWH on DTG + TDF/FTC (+0.16 ± 0.28) and DTG + ABC/3TC (+0.1 ± 0.3). In the SCOLTA cohort, PWH on 2DRs experienced a CD4/CD8 increase only in the DTG + 3TC group. Controlled studies with longer follow-up will clarify the long-term immunological and clinical impacts of DTG-2DR. [ABSTRACT FROM AUTHOR]