학술논문
9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds.
Document Type
Article
Author
Source
Subject
*FLUORENONE
*CHEMICAL synthesis
*CELL lines
*FLOW cytometry
*FIRE assay
*
*
*
*
Language
ISSN
2192-6506
Abstract
The introduction of a hydrophobic group at position 7 of 9-fluorenone-2-carboxylic acid generates new tubulin binders, the design of which is suggested by modeling studies. The synthesis is based on the use of 2,7-dibromo-fluorenone as starting material. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism. [ABSTRACT FROM AUTHOR]