학술논문
Glutathione S-transferase M1 and T1 genes deletion polymorphisms and blood pressure control among treated essential hypertensive patients in Burkina Faso.
Document Type
Article
Author
Sombié, Herman Karim; Tchelougou, Daméhan; Ouattara, Abdoul Karim; Kologo, Jonas Koudougou; Sorgho, Pegdwendé Abel; Somda, Dogfunianalo; Yaméogo, Sakinata; Zongo, Arsène Wendpagnangdé; Kiendrebeogo, Isabelle Touwendpoulimdé; Adoko, Enagnon Tiémoko Herman Donald; Yonli, Albert Théophane; Djigma, Florencia Wendkuuni; Zabsonré, Patrice; Millogo, Hassanata; Simporé, Jacques
Source
Subject
*GLUTATHIONE transferase
*HYPERTENSION
*GENETIC polymorphisms
*DELETION mutation
*ESSENTIAL hypertension
*GLUTATHIONE
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Language
ISSN
1756-0500
Abstract
Objective: Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional study in Burkina Faso consisted of 200 patients with essential hypertension and under treatment. Results: In the present study, 57.5% (115/200) of patients had their hypertension under control. No statistically significant difference was found between controlled and uncontrolled groups for anthropometric and biochemical parameters as well as for GSTT1 or GSTM1 gene polymorphisms (all p > 0.05). Current alcohol consumption (OR = 3.04; CI 1.88–6.13; p < 0.001), Physical inactivity (OR = 3.07; CI 1.71–5.49; p < 0.001), severe hypertension before any treatment (Grade III [OR = 3.79; CI 2.00–7.17; p < 0.001]) and heart damage (OR = 3, 14; CI 1.59–6.02; p < 0.001) were statistically more frequent in uncontrolled essential hypertensive patients than controlled hypertensive patients. [ABSTRACT FROM AUTHOR]