학술논문

Chemical Biology of Nucleic Acid Modifications – Celebrating the Groundbreaking Contributions of Chuan He.
Document Type
Article
Source
Israel Journal of Chemistry. Mar2024, Vol. 64 Issue 3/4, p1-3. 3p.
Subject
*NUCLEIC acids
*CHEMICAL biology
*BIOCHEMISTRY
*RNA modification & restriction
*RNA-protein interactions
*CYTOSINE
*TRANSFER RNA
Language
ISSN
0021-2148
Abstract
This special issue of the Israel Journal of Chemistry celebrates the groundbreaking contributions of Chuan He, who was awarded the prestigious Wolf Prize in Chemistry in 2023 for his work on RNA modification. The issue features contributions from He's past trainees, collaborators, and colleagues, focusing on the chemical biology of nucleic acid modifications. The collection includes research and review articles that highlight the wide-ranging impact of He's work in areas such as epigenetics, epitranscriptomics, and gene regulation. The articles cover various nucleic acid modifications, including f5C, m6A, pseudouridine, and 2'-O-methylation, and explore their biological functions and detection methods. The issue also discusses emerging areas in nucleic acid biology, such as engineered RNA-binding proteins and spatially resolved transcriptomics. Overall, this special issue showcases the transformative power of chemical biology in nucleic acid modification research and celebrates He's influential role in the field. [Extracted from the article]