학술논문
Urinary F2 -isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia.
Document Type
Article
Author
Source
Subject
*BRONCHOPULMONARY dysplasia
*ISOPROSTANES
*PROGNOSIS
*PEROXIDATION
*PREMATURE infants
*PREGNANCY
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Language
ISSN
0743-8346
Abstract
Objective:Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F2-isoprostanes (F2-IsoP). We hypothesized that urinary excretion of the stable metabolite of F2-IsoP, 8-iso-PGF2α, would be higher in infants who develop BPD than those who did not.Methods:Forty infants <30-weeks gestational age (GA) were enrolled, 24 infants with BPD and 16 without BPD. Urine specimens were collected weekly and stored at −80°C until analyzed. Urinary 8-iso-PGF2α was measured by gas chromatography/mass spectrometry (GC-MS) and normalized to creatinine excretion.Results:GA and birth weight (BW) were lower in infants who developed BPD than those who did not. Urinary 8-iso-PGF2α levels in the first or third weeks of age were not significantly different between the two groups.Conclusion:Urinary excretion of 8-iso-PGF2α in early postnatal life in preterm infants is not correlated with the development of BPD.Journal of Perinatology (2007) 27, 303–306. doi:10.1038/sj.jp.7211684; published online 15 March 2007 [ABSTRACT FROM AUTHOR]