학술논문
β-hairpin polypeptides by design and selection.
Document Type
Article
Author
Source
Subject
*PEPTIDES
*PROTEIN folding
*NUCLEAR magnetic resonance spectroscopy
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Language
ISSN
0712-4813
Abstract
We have developed polypeptide scaffolds that readily adopt a β-hairpin conformation (a pair of antiparallel strands connected by a turn) in solution. The study of such peptides allows us to understand the factors that govern stability and folding of these motifs in proteins, and permits mimicry of functionally important regions of proteins. Spectroscopic and biophysical methods have been used to characterize the conformational preferences and stability of these peptides, with a strong emphasis on using restraints generated from [ABSTRACT FROM AUTHOR]