학술논문
Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.
Document Type
Article
Author
Source
Subject
*NICOTINAMIDE nucleotides
*VASCULAR diseases
*OXIDATIVE stress
*CELLULAR aging
*LABORATORY mice
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Language
ISSN
1474-9718
Abstract
We tested the hypothesis that supplementation of nicotinamide mononucleotide ( NMN), a key NAD+ intermediate, increases arterial SIRT1 activity and reverses age-associated arterial dysfunction and oxidative stress. Old control mice ( OC) had impaired carotid artery endothelium-dependent dilation ( EDD) (60 ± 5% vs. 84 ± 2%), a measure of endothelial function, and nitric oxide ( NO)-mediated EDD (37 ± 4% vs. 66 ± 6%), compared with young mice ( YC). This age-associated impairment in EDD was restored in OC by the superoxide ( [ABSTRACT FROM AUTHOR]