학술논문
IAPs, TNF, inflammation and Jürg TSCHOPP; a personal perspective.
Document Type
Editorial
Author
Source
Subject
*TUMOR necrosis factors
*PERFORINS
*CELL death
*APOPTOSIS
*
*
*
Language
ISSN
1350-9047
Abstract
The article comments on the contribution of researcher Jürg Tschopp to the tumor necrosis factor (TNF) signalling field. The author observes that Tschopp was the first to identifiy perforin and at the same time as another group, characterised its role in cytolytic T-cell mediated lysis. He showed that Fas (CD95) also contributes to this process, which started his pathbreaking contributions to the TNF field. He describes the dissection of TNF receptor 1 (TNFR1) signalling.